Transcription is a key regulatory step for a specific set of gene expression, which in turn globally programs or reprograms the cellsin response to a variety of physiological or stress signals. In eukaryote cells, transcription factors as well as cofactors are centered on the specific enhancer regions of genes to form high-order regulatory assemblies. Themost, if not all, of these cofactors are histone modification enzymes that convey a variety of upstream signals to epigenetic marks. Our lab is taking a structura land functional approach to unravel molecular mechanisms of the epigenetic modifications and transcriptional regulation, in particular the histone acetylation by p300/CBP and PCAF/GCN5. In prokaryotic cells, two-component system (TCS), which typically consists of a histidine kinase (SK) and a cognate response regulator (RR), is a major signal transduction pathway responsible for stimuli induced reprogramming process. Our lab uses an essential TCS, VicRK, also called YycFG or WalRK, in many gram+ bacteria as a model system tounderstand how the intra/extracellular signals regulate the transcription of bacteria.

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