Transcription is a key regulatory step for a specificset of gene expression, which in turn globally programs or reprograms the cellsin response to a variety of physiological or stress signals. In eukaryotecells, transcription factors as well as cofactors are centered on the specificenhancer regions of genes to form high-order regulatory assemblies. Themost, if not all, of these cofactors are histone modification enzymes thatconvey a variety of upstream signals to epigenetic marks. Our lab is taking a structuraland functional approach to unravel molecular mechanisms of the epigeneticmodifications and transcriptional regulation, in particular the histoneacetylation by p300/CBP and PCAF/GCN5. In prokaryotic cells, two-componentsystem (TCS), which typically consists of a histidine kinase (SK) and a cognateresponse regulator (RR), is a major signal transduction pathway responsible forstimuli induced reprogramming process. Our lab uses an essential TCS, VicRK, alsocalled YycFG or WalRK, in many gram+ bacteria as a model system tounderstand how the intra/extracellular signals regulate the transcription ofbacteria.

Amazing Beauty of Science